| 12/04/2021 | ||
| Atlético Tucumán | 2 - 0 | Vélez Sarsfield |
| Lanús | 1 - 3 | Newell's Old Boys |
| Huracán | 3 - 0 | Sarmiento |
| 11/04/2021 | ||
| River Plate | 3 - 2 | Colón |
| Unión | 1 - 0 | Boca Juniors |
| Rosario Central | 3 - 1 | Banfield |
| Atlético Patronato | 4 - 1 | Gimnasia La Plata |
| Argentinos Juniors | 0 - 0 | Central Córdob… |
| Godoy Cruz | 2 - 3 | Arsenal |
| 10/04/2021 | ||
| Racing Club | 1 - 0 | Independiente |
| Defensa y Justicia | 2 - 2 | Talleres de Có… |
| Estudiantes | 1 - 0 | Aldosivi |
| 09/04/2021 | ||
| Platense | 2 - 4 | San Lorenzo |
| 05/04/2021 | ||
| Banfield | 2 - 2 | Estudiantes |
| 04/04/2021 | ||
| Racing Club | 2 - 4 | Godoy Cruz |
| Vélez Sarsfield | 4 - 1 | Unión |
| Colón | 0 - 0 | Argentinos Juniors |
| Newell's Old Boys | 2 - 2 | Huracán |
| 03/04/2021 | ||
| Arsenal | 0 - 0 | River Plate |
