| 04/06/2021 | ||
| Colón | 3 - 0 | Racing Club |
| 31/05/2021 | ||
| Independiente | 0 - 2 | Colón |
| Racing Club | 0 - 0 | Boca Juniors |
| 16/05/2021 | ||
| Boca Juniors | 1 - 1 | River Plate |
| Vélez Sarsfield | 0 - 0 | Racing Club |
| 15/05/2021 | ||
| Colón | 1 - 1 | Talleres de Có… |
| Estudiantes | 0 - 0 | Independiente |
| 09/05/2021 | ||
| Newell's Old Boys | 1 - 1 | Sarmiento |
| Lanús | 1 - 0 | Talleres de Có… |
| Huracán | 1 - 3 | Independiente |
| Colón | 1 - 1 | Unión |
| Platense | 4 - 1 | Rosario Central |
| Racing Club | 2 - 0 | San Lorenzo |
| River Plate | 4 - 1 | Aldosivi |
| Argentinos Juniors | 2 - 0 | Estudiantes |
| Arsenal | 1 - 1 | Central Córdob… |
| 08/05/2021 | ||
| Atlético Patronato | 1 - 0 | Boca Juniors |
| Gimnasia La Plata | 0 - 5 | Vélez Sarsfield |
| Atlético Tucumán | 5 - 0 | Defensa y Justicia |
| Godoy Cruz | 0 - 1 | Banfield |
