| 17/01/2021 | ||
| Banfield | 1 - 1 | Boca Juniors |
| 16/01/2021 | ||
| Rosario Central | 1 - 3 | Vélez Sarsfield |
| 14/01/2021 | ||
| Defensa y Justicia | 4 - 4 | Aldosivi |
| 11/01/2021 | ||
| Estudiantes | 1 - 2 | Central Córdob… |
| 10/01/2021 | ||
| Colón | 1 - 2 | Talleres de Có… |
| Banfield | 4 - 1 | San Lorenzo |
| Gimnasia La Plata | 0 - 1 | Atlético Tucumán |
| Arsenal | 1 - 0 | Huracán |
| 09/01/2021 | ||
| Argentinos Juniors | 2 - 2 | Boca Juniors |
| River Plate | 0 - 2 | Independiente |
| Racing Club | 3 - 1 | Newell's Old Boys |
| Vélez Sarsfield | 3 - 2 | Godoy Cruz |
| Lanús | 2 - 0 | Rosario Central |
| Unión | 1 - 2 | Atlético Patronato |
| 05/01/2021 | ||
| Atlético Tucumán | 0 - 2 | Colón |
| Huracán | 0 - 1 | Argentinos Juniors |
| Godoy Cruz | 1 - 0 | Estudiantes |
| 04/01/2021 | ||
| Talleres de Có… | 3 - 2 | Banfield |
