| 19/09/2021 | ||
| River Plate | 1 - 0 | Arsenal |
| Huracán | 0 - 1 | Independiente |
| Platense | 0 - 0 | Argentinos Juniors |
| Colón | 1 - 0 | Central Córdob… |
| Atlético Patronato | 1 - 2 | Estudiantes |
| 18/09/2021 | ||
| Atlético Tucumán | 1 - 2 | Boca Juniors |
| Racing Club | 1 - 2 | Talleres de Có… |
| Vélez Sarsfield | 3 - 2 | Aldosivi |
| Godoy Cruz | 1 - 1 | Sarmiento |
| 15/09/2021 | ||
| Newell's Old Boys | 1 - 4 | River Plate |
| Banfield | 1 - 2 | Rosario Central |
| Argentinos Juniors | 1 - 1 | Atlético Patronato |
| Unión | 0 - 2 | Estudiantes |
| 14/09/2021 | ||
| Boca Juniors | 0 - 0 | Defensa y Justicia |
| Central Córdob… | 2 - 0 | Atlético Tucumán |
| Arsenal | 0 - 0 | Colón |
| Talleres de Có… | 2 - 1 | Platense |
| 13/09/2021 | ||
| Gimnasia La Plata | 0 - 0 | Vélez Sarsfield |
